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Welcome To Plan Pharmaceuticals

RU-486 or mifepristone (Mifegyne ® ) is a 19-norsteroid derived from norethindrone, a synthetic progestin of the first generation with potent antiprogestative activity by behaving like a partial agonist of progesterone receptors. Resulting from research conducted by Étienne-Émile Baulieu, its structure is similar to that of progesterone and glucocorticoids, but two molecular substitutions, one in 17α gives it greater affinity than norethindrone, and the other in 11β induced , or stabilizes the inert conformation of the receptor.

The binding of mifepristone to the progesterone receptor (PR) leads to inactivation of the PR explaining the effectiveness of its anti-progesterone action . The digestive absorption after oral intake is rapid and the plasma protein binding rate is 98% with a hepatic metabolism and elimination via the faeces.

Mifepristone is available as 200 mg tablets. Its cost is 20 euros per tablet ( Vidal 2004).

Since the development of mifepristone, several hundred related compounds have been discovered. These molecules have various actions, ranging from an agonist effect of progesterone to an agonist-antagonist action. All these molecules belong to the family of SPRMs ( Selective Progesterone Receptor Modulators )

 

What is XANAX used for?

Symptomatic treatment of severe and / or disabling anxiety symptoms,

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Conditions for which this medication may be prescribed

  • Severe and / or disabling anxiety disorder
  •  
  • Delirium tremens and other manifestations of alcohol withdrawal

Method of administration and dosage of the drug XANAX

Reserved for adults

The 0.25 mg dosage is more particularly suited to the elderly, to renal or hepatic insufficiency.

Dosage

In all cases, treatment will be started at the lowest effective dose and the maximum dose of 4 mg / day will not be exceeded.

In general, in adults, treatment will be started at a dosage of 0.75 mg to 1 mg per day, divided into 3 divided doses as follows:

0.25 mg in the morning and at noon, and 0.25 to 0.50 mg in the evening.

The dosage will then be adapted individually depending on the therapeutic response.

The average dosage is between 1 and 2 mg per day.

In the elderly, kidney or liver failure : it is recommended to reduce the dosage, for example by half.

The safety and efficacy of alprazolam have not been studied in children and adolescents under the age of 18 years. Its use is not recommended in this population.

Duration 

Treatment should be as brief as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should not exceed 8 to 12 weeks for the majority of patients, including the period of reduction of the posology (see section Warnings and precautions for use).

In some cases, it may be necessary to extend the treatment beyond the recommended periods. This requires precise and repeated assessments of the patient’s condition.

Prevention and treatment of delirium tremens, and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days.

Administration mode

 

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